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Klimodien (dienogest and estradiol valerat)
Klimodien is a continuous combined hormone replacement therapy (HRT) for oral use in women with an intact uterus. The product consists of a fixed combination of two active ingredients, estradiol valerate 2 mg and dienogest 2 mg. For The Netherlands, dienogest, a derivative of nortestosterone, is a new progestagen. Dienogest is the active ingredient of two oral combined contraceptives that are marketed only in Germany in 1991 and 1995, respectively Certostat (ethinyl estradiol 50 mg + dienogest 2 mg) and its successor Valette (30 mg ethinyl estradiol + dienogest 2 mg). The rationale for the development of a new progestagen like dienogest was to have a progestagen with strong anti-estrogenic and progestational effect and no androgenic effect.
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