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Sofradex (Dexamethasone, Framycetin, Gramicidin) Synonyms: Sofradex
Sofradex (Dexamethasone, Framycetin, Gramicidin) - the antibiotics soframycin (framycetin sulphate) and gramicidin will control and eradicate most superficial bacterial infections of the eye and ear, whilst the dexamethasone will suppress inflammation and control any pruritus and exudate which may be present.
Active Ingredients: Dexamethasone, Framycetin, Gramicidin
Therapeutic actions: Dexamethasone belongs to a type of drugs, known as corticosteroids, that are used to reduce eye inflammation(redness, irritations,swelling or burning of the eye). Dexamethasone interacts with specific protein receptors, regulating the expression of the corticoid- dependant genes. It also works by stabilizing the lysosomal ferments, inhibiting the mitosis and migration of leukocytes. As a result the number of chemicals that are important in inflammation precess is decreased. Framycetin sulphate is an aminoglycosid antibiotic.
Framycetin works by binding to proteins structure of the bacteria's cells. As a result, bacteria start to produce the abnormal proteins. The production of these abnormal proteins is ultimately fatal for the bacteria.
Gramicidin is also an antibacterial medicine. Gramicidin exerts bacteriostatic and in the high doses bactericidal action. It works by increasing the permeability of the bacterial cell for the inorganic cations due to building the network of channels in the lipid structures of the membrane. This ,in its turn, causes the development of the osmotic instability of cell.
What is it used for?: (Indications:) Sofradex (Dexamethasone, Framycetin, Gramicidin) is used to prevent and treat inflammation of the eye caused by bacteria . Eye inflammation involves the following conditions:
Contraindications and cautions: You should not use Sofradex:
• if you have an allergy to any of Sofradex ingredients • if you have eye infection that produces pus • if you have eye infection caused by fungi • if you suffer from glaucoma • if you experience inflammation of cornea or conjunctiva caused herpes simplex virus (herpetic keratitis) • if you experience eye infection caused by Tuberculosis • if you have viral infections of the eye
You should use Sofradex drops with caution
• in children • in pregnancy • in breastfeeding • in prolonged use
• You should regularly examine your eye condition while you taking tSofradex, as it can some cause eye disturbances. Consult your doctor if you experience any disturbances in your vision while taking this medicine. • Tell your health care provider if after seven days of treatment with Sofradex you do not experience any improvements. • Sofradex may cause temporarily blurry vision . Do not drive or operate machinery unless the vision is clear. • Prolonged or intensive use of Sofradex may lead to an increase of intraocular pressure. This, in its turn, may cause cataracts, glaucoma and damage to the optic nerve. • Do not take this medication by mouth. • Do not use Sofradex to treat redness of the eye that is not diagnosed by your health care provider. Inappropriate use of Sofradex can cause blindness. • Prolonged use of Sofradex may increase the risk of adrenal suppression in infants
Side effects: There are possible side-effects associated with this medicine that can affect individuals in different ways. If a side effect is stated here, that does not necessarily mean the fact that all people using Sofradex will experience it or any other.
• Itching • Stinging • Partial loss of vision due cataracts • Irritation • Burning sensation • dermatitis • Increased intraocular pressure
The side effects listed above may not include all of the side effects reported by the drug's manufacturer. For more information about any other possible risks associated with , please read the information provided with Sofradex drops or consult your doctor or pharmacist.
Interactions: It is important to tell your doctor or pharmacist what medicines you are already taking, including those bought without a prescription and herbal medicines, before you start treatment with Sofradex. Similarly, check with your doctor or pharmacist before taking any new medication while taking this one, to ensure that the combination is safe. Especially pay attention to other eye medications, containing corticosteroids and antibiotics.