Therapeutic actions: Inhibits protein synthesis in susceptible bacteria by binding to 30S ribosomal subunits.
What is it used for?: Treatment of HIV infection in combination with other agents. Aminoglycoside antibiotics, including amikacin, are used primarily to treat infections caused by aerobic gram-negative bacilli. Peak levels are necessary to assure adequate therapeutic levels for organism being treated.
Contraindications and cautions: • allergy to any ingredient in Amikin or other aminoglycoside antibiotics (eg, gentamicin)
Side effects: Less serious side effects:breathing difficulty; loss of balance. Serious side effects:severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); decreased urination; dizziness; hearing loss; lightheadedness; muscle weakness; numbness or tingling; ringing or roaring in the ears; vaginal irritation or discharge.
Interactions: • Anesthetics (eg, succinylcholine) or neuromuscular blockers (eg, tubocurarine) may provoke severe muscle relaxation progressing to paralysis and lack of breathing; • The risk of kidney damage or hearing loss may be increased by amphotericin B, bacitracin, cephalosporins (eg, cephaloridine), cisplatin, colistin, loop diuretics (eg, furosemide), nonsteroidal anti-inflammatory drugs (NSAIDs) (eg, ibuprofen), other aminoglycosides (eg, gentamicin), polymyxin B, or vancomycin.