Inhibits bacterial cell wall synthesis by binding to one or more of the penicillin-binding proteins (PBPs) which in turn inhibits the final transpeptidation step of peptidoglycan synthesis in bacterial cell walls, thus inhibiting cell wall biosynthesis. Bacteria eventually lyse due to ongoing activity of cell wall autolytic enzymes (autolysins and murein hydrolases) while cell wall assembly is arrested.
What is it used for?:
• Treatment of respiratory tract, skin and skin structure, genital, urinary tract, biliary tract, bone and joint infections, and septicemia due to susceptible gram-positive cocci (except enterococcus); some gram-negative bacilli including E. coli, Proteus, and Klebsiella may be susceptible; perioperative prophylaxis;
• Alternative antibiotic for prevention of infective endocarditis when parenteral administration is needed.
• Prophylaxis against infective endocarditis Contraindications and cautions: • allergy to any drugs (especially penicillins);
• kidney disease;
• liver disease;
• a stomach or intestinal disorder such as colitis.
Side effects: Serious side effects:
• diarrhea that is watery or bloody;
• skin rash, bruising, severe tingling, numbness, pain, muscle weakness;
• fever, chills, body aches, flu symptoms;
• easy bruising or bleeding, unusual weakness;
• fever, sore throat, and headache with a severe blistering, peeling, and red skin rash; or
• seizure (black-out or convulsions). Less serious side effects:
• pain, swelling, skin rash, or a hard lump where the injection was given;
• stomach pain, nausea, vomiting, loss of appetite;
• skin rash or itching;
• white patches or sores inside your mouth or on your lips; or
• vaginal itching or discharge.
Do not use this medication if you are allergic to cefazolin, any type of penicillin, or to other cephalosporin antibiotics, such as:
• cefaclor (Ceclor);
• cefadroxil (Duricef);
• cefdinir (Omnicef);
• cefditoren (Spectracef);
• cefixime (Suprax);
• cefotaxime (Claforan;
• cefprozil (Cefzil);
• ceftazidime (Fortaz);
• cefuroxime (Ceftin);
• cephalexin (Keflex); and others.