Therapeutic actions: Lisinopril is part of a class of drugs called ACE inhibitors .ACE stands for angiotensin-converting enzyme. Lisinopril helps block this enzyme, which is normally part of a reaction in the body that causes the blood vessels to narrow (constrict). By blocking this enzyme, Lisinopril causes blood vessels to relax, which can lower blood pressure. By helping blood vessels relax, lisinopril also increases the efficiency of the heart. This means that the heart does not have to work as hard and more blood can be pumped out to the rest of the body. Both of these are helpful for a person with congestive heart failure.
Indications: Lisinopril has been licensed to treat several conditions related to the heart and blood vessels. Some uses of lisinopril include: • Controlling high blood pressure (hypertension) • Treating congestive heart failure • Improving survival following a heart attack. Lisinopril has also been approved as a treatment for high blood pressure in children 6 years of age and older.
Contraindications and cautions:
You should not take lisinopril if:
• You are pregnant. If you become pregnant while taking lisinopril, call your doctor immediately. Lisinopril may harm the fetus. • You are allergic to lisinopril, or any inactive component used to make lisinopril. Your healthcare provider or pharmacist has a list of inactive ingredients. • You have a history of angioedema related to previous ACE inhibitor treatment. • You have hereditary or idiopathic angioedema.
You should talk with your healthcare provider prior to taking lisinopril if you have:
• Heart disease, including congestive heart failure, aortic stenosis, or hypertrophic cardiomyopathy • Liver disease, including cirrhosis • Kidney disease or kidney failure • Diabetes • Scleroderma • Systemic lupus erythematosus (lupus or SLE) • A personal or family history of angioedema, which is swelling under the skin • Any allergies, including allergies to ACE inhibitors, foods, dyes, or preservatives.
Also let your healthcare provider know if you:
• Are breastfeeding • Are on dialysis • Will be undergoing surgery or anesthesia
Adverse effects: Medicines and their possible side effects can affect individual people in different ways. The following are some of the side effects that are known to be associated with this medicine. Because a side effect is stated here, it does not mean that all people using this medicine will experience that or any side effect.
Lisinopril may cause side effects. • cough • dizziness • headache • excessive tiredness • upset stomach • diarrhea • weakness • sneezing • runny nose • decrease in sexual ability • rash
Some side effects can be serious. The following symptoms are uncommon, but if you experience any of them, call your doctor immediately:
• swelling of the face, throat, tongue, lips, eyes, hands, feet, ankles, or lower legs • hoarseness • difficulty breathing or swallowing • fever, sore throat, chills, and other signs of infection • yellowing of the skin or eyes • lightheadedness • fainting • chest pain The side effects listed above may not include all of the side effects reported by the drugis manufacturer. For more information about any other possible risks associated with this medicine, please read the information provided with the medicine or consult your doctor or pharmacist.
Interactions: It is important to tell your doctor or pharmacist what medicines you are already taking, including those bought without a prescription and herbal medicines, before you start treatment with this medicine. Similarly, check with your doctor or pharmacist before taking any new medicines while taking this one, to ensure that the combination is safe. Especially pay attention to the following drugs: • Diuretics, such as torsemide (Demadex®), furosemide (Lasix®), hydrochlorothiazide, and others • Nonsteroidal anti-inflammatory drugs (NSAIDs), such as: o Ibuprofen (Motrin®, Advil®) o Naproxen (Naprosyn®) o Naproxen sodium (Aleve®, Anaprox®, Naprelan®) o Diclofenac (Cataflam®, Voltaren®) o Indomethacin (Indocin®) o Nabumetone (Relafen®) o Oxaprozin (Daypro®) o Celecoxib (Celebrex®) o Meloxicam (Mobic®) o Etodolac (Lodine®) o Ketoprofen o Ketorolac (Toradol®). • Potassium supplements • Potassium-sparing diuretics, such as spironolactone (Aldactone®), triamterene (Dyrenium®), and amiloride (Midamor®), among others • Lithium (Eskalith®, Lithane®, Lithonate®, Lithotabs®).